MMSC
What are Multipotent Mesenchymal Stem Cells (MMSCs)?

MMSCs are allogeneic embryonic stem-cell-derived mesenchymal stem cells that have been differentiated and purified through our company’ s ENS platform technology.
The cells meet all MSC standards as regulated by the International Society for Cellular Therapy (ISCT), and have been developed and produced to be used for medical therapy.

In comparison to prior adult cell origin MSC, the immune rejection response was shown to be extremely low and that the secretion of useful substances, anti-inflammatory ability, etc. were shown to be excellent.
Supplier of a new MSC that offers convenient production and quality assurance.
  • Most stem cell therapies all around the world use mesenchymal stem cells (MSC).
  • Most stem cell therapies currently being sold are MSC that have been derived from adult cells: bone marrow, cord blood, adipose tissue, etc.
  • Mesenchymal stem cells have excellent proliferative capacities, immune system regulation, and anti-inflammatory effects.
Embryonic Stem Cells
Proliferative Capacity
Infinite proliferative capacity
Consistency
Almost no deviation
Functionality
Abundant secretome
Production Method
Consistent, simplified
Treatment Effects
Clear MoA
Safety
No possibility of tumor formation
Adult Stem Cells
Proliferative Capacity
Limited proliferative capacity
Consistency
Large deviations dependent on donor
Functionality
Limited secretome
Production Method
Variable, complicated
Treatment Effects
Uncertain MoA
Safety
No immune rejection

MMSCs are excellent, high-functional cells that have been shown to be superior to previously used adult stem cells in categories such as proliferative capacity, genetic safety, immunogenicity, anti-inflammatory effects, long-term viability, engraftment, etc. MMSCs also offer the possibility for their indications to be expanded and to be used for various diseases.

MMSC: Next-generation cell therapy with great potential for expansion of indications!
  • Urological Disorders

    Reliable blood vessel regeneration and tissue regeneration compared to prior adult stem cell therapies

  • Autoimmune Disorders

    Strong immune suppression and immune tolerance compared to prior adult stem cell therapies

  • Musculoskeletal Disorders

    Conversion to muscle cells, etc.
    compared to prior adult stem cell therapies

  • Immune Related Disorders

    Excellent anti-inflammatory effects compared to prior adult stem cell therapies

  • Cardiovascular Disorders

    Long term viability and conversion to muscle cells, etc. compared to prior adult stem cell therapies

Possesses qualities of MSC as defined by the International Society for Cellular Therapy (ISCT)
  • Attachment
  • Phenotype
    • - 95%

      Positive
      (CD73, CD90, CD105)

    • - 2%

      Negative
      (CD45, CD34, CD19, CD14, HLA-DR)

  • Differentiation
Residual amount of undifferentiated embryonic stem cells
  • FACS
    • 0.15%
  • qPCR
    • 0.00
  • RNA seq.
    • 0
Excellent Functionality of MMSC
  • Angiogenesis
  • Wound Healing Ability
  • Immune Modulation (BrdU)
    • 0.8
      MMSC
    • 0.8
      MMSC + PBMC
    • 0.9
      PBMC
    • 1.7
      PBMC + (PBMC + PHA)
    • 2.2
      PBMC + PHA
  • Immune Modulation (IFN-γ)
    • MMSC
    • MMSC + PBMC
    • PBMC
    • 508.4
      PBMC + (PBMC + PHA)
    • 1095.5
      PBMC + PHA
  • Material Exchange Ability
    • 0h
    • 46.15%
      48h
Comparison to BM-MSC
  • Wound Healing Ability [Unit: cells]
    • 90
    • 330

      *migrating cell numbers : about 3.5 times ▲

  • Secretion of functional substances
    and expression of apoptosis factors     [Unit: pg/mL]
    • 1,237
    • 20,953

      * MMP-1 conc. about 17 times ▲

    • 534
    • 1,360

      * HGF conc. about 2.5 times ▲

    • 800
    • 53

      * Fas conc. about 15 times ▼

  • Proliferative Capacity [Unit: PDL]
    • 10.17
    • 16.13

      * Cumulative PDL : about 1.6 times ▲

  • Cell Size [Unit: μm]
    • 17.3
    • 13.6

      * about 1.3 times ▼

  • Inflammatory and Immune Response
    • 1

    • * Gata3: about 100.8 times ▲

    • * Adora2a: about 28 times ▲

    • * Gps2: about 11 times ▲

    • * Psma1: about 9.1 times ▲

    • * Pbk: about 7.1 times ▲

    • * Lrfn5: about 7.1 times ▲

    • * Apoe: about 5.5 times ▲

    • * Foxf1: about 4.8 times ▲

    • * Tek: about 4 times ▲

    • * Cx3cl1: about 3.6 times ▲

Do you need MMSC samples for the development of medical treatment in the research stage?

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Do you need MMSC samples with high secretory abilities to utilize useful substances secreted by stem cells?

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